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    1. Neuronal Signaling
    2. Serotonin Transporter

    Serotonin Transporter

    Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.

    Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.

    Serotonin Transporter 相关产品 (43):

    Cat. No. Product Name Effect Purity
    • HY-B0102A
      Fluoxetine hydrochloride Inhibitor 99.86%
      Fluoxetine hydrochloride是抗抑郁药和选择性的血清素重吸收抑制剂。
    • HY-42110
      Dopamine serotonin antagonist-1 Antagonist 99.79%
      Dopamine serotonin antagonist-1是 dopamineserotonin 受体拮抗剂,对多巴胺D1,D2,D4和血清素S2A,S2C,S3的 Ki 值分别为200,2500,420,39,84,40 nM。
    • HY-B0492
      Paroxetine hydrochloride Inhibitor >99.0%
      Paroxetine hydrochloride 是一种抗抑郁药,为高效的五羟色胺再摄取抑制剂,能抑制 GRK2 活性,IC50 值为 14?μM。
    • HY-B0176A
      Sertraline hydrochloride Inhibitor 99.84%
    • HY-B0103A
      Fluvoxamine maleate Inhibitor 99.85%
      Fluvoxamine (maleate) (DU-23000 (maleate)) 是5-羟色胺再吸收抑制剂,有抗抑郁活性。
    • HY-N0173
      Cinchonidine Inhibitor >98.0%
      Cinchonidine (α-Quinidine) 是在金鸡纳和角蒿中发现的金鸡纳生物碱。 Cinchonidine (α-Quinidine) 是用于有机化学中不对称合成的砌块。是血清素转运蛋白 (SERT)的弱抑制剂,对于dSERT,hSERT,hSERT I172M,hSERT S438T,hSERT Y95F的 Ki 分别为330,4.2,36,196,15 μM。有抗疟活性.。
    • HY-18332C
      DOV-216,303 Free Base Inhibitor 98.47%
      DOV-216,303 (Free Base) 是有效的 5-羟色胺、去甲肾上腺素、多巴胺再摄取的三重抑制剂,其对 hSERT、hNET 和 hDAT 的 IC50 值分别为 14 nM,20 nM和78 nM。在嗅球切除大鼠模型中,可增加前额皮质中单胺的释放及具有抗抑郁的作用。
    • HY-111419
      DSP-1053 Inhibitor
      DSP-1053是有效地 SERT (Ki=1.02 nM) 抑制剂,具有部分5-HT1A (Ki=5.05 nM) 激动剂作用。
    • HY-B1490
      Imipramine hydrochloride Inhibitor 99.89%
      Imipramine hydrochloride抑制血清素转运蛋白(serotonin),体内试验的IC50值为32 nM.
    • HY-B0161A
      Duloxetine hydrochloride Inhibitor 99.92%
      Duloxetine盐酸盐是5-羟色胺-去甲肾上腺素重吸收抑制剂(SNRI),Ki为 4.6 nM。
    • HY-B1287
      Citalopram hydrobromide Inhibitor >99.0%
      Citalopram盐酸盐是选择性的血清素再摄取抑制剂 (SSRI) 类的抗抑郁药, 已被FDA批准用于治疗抑郁症。
    • HY-B0602A
      Desvenlafaxine succinate hydrate Inhibitor 99.76%
    • HY-B0457
      Clomipramine hydrochloride Inhibitor 99.72%
      Clomipramine盐酸盐是5-羟色胺转运体(SERT)、去甲肾上腺素转运体(NET)和多巴胺转运体(DAT)阻断剂,Ki分别为0.14,54和3 nM。
    • HY-B0196A
      Venlafaxine hydrochloride Inhibitor 99.75%
    • HY-15414
      Vortioxetine Inhibitor 98.81%
      Vortioxetine 是 5-HT1A,5-HT1B,5-HT3A,5-HT7 受体 和 5-羟色胺转运体 (SERT) 的抑制剂,其 Ki 值分别为 15 nM,33 nM,3.7 nM,19 nM 和 1.6 nM。
    • HY-14258A
      Escitalopram oxalate Inhibitor >98.0%
      Escitalopram是选择性5羟色胺重吸收抑制剂(SSRI),Ki为0.89 nM。
    • HY-15414A
      Vortioxetine hydrobromide Inhibitor 99.54%
      Vortioxetine hydrobromide 是5-HT1A,5-HT1B,5-HT3A,5-HT7 受体 和5-羟色胺转运体 (SERT) 的抑制剂,其Ki值分别为 15 nM,33 nM,3.7 nM,19 nM 和 1.6 nM。
    • HY-12850A
      Dasotraline hydrochloride Inhibitor 99.60%
      Dasotraline hydrochloride (SEP-225289 hydrochloride) 是具有阻断多巴胺,去甲肾上腺素和三羟色胺转运蛋白的三重再摄取抑制剂,IC50值分别为4,6和11 nM。
    • HY-14261
      Vilazodone Hydrochloride Inhibitor 99.94%
      Vilazodone Hydrochloride 是 5-羟色胺转运体 (SER) 的抑制剂和 5-HT1A 受体的部分激动剂。
    • HY-B0725
      Doxepin Hydrochloride Inhibitor 99.41%
    Isoform Specific Products

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