<noframes id="zd9f3">

    <address id="zd9f3"></address>

    <address id="zd9f3"></address>
    <address id="zd9f3"></address>

    <address id="zd9f3"><nobr id="zd9f3"><meter id="zd9f3"></meter></nobr></address>
    1. Stem Cell/Wnt
    2. Smo


    Smoothened is a G protein-coupled receptor protein encoded by the SMO gene of the hedgehog signaling pathway conserved from flies to humans. It is the molecular target of the teratogen cyclopamine. Cellular localization plays an essential role in the function of SMO. Stimulation of the patched receptor by the sonic hedgehog ligand leads to translocation of SMO to the primary cilium. Furthermore, SMO that is mutated in the domain required for ciliary localisation cannot contribute to pathway activation.[3] SMO has also been shown to bind the kinesin motor protein Costal-2 and play a role in the localization of the Ci (Cubitus interruptus transcription factor) complex. SMO can function as an oncogene. Activating SMO mutations can lead to unregulated activation of the hedgehog pathway and cancer.

    Smo 相关产品 (16):

    Cat. No. Product Name Effect Purity
    • HY-12848
      SAG Agonist 99.71%
      SAG 是一种有效的 Smo 受体 激动剂,能够活化 Hedgehog 信号通路,Kd 值为 59 nM。
    • HY-15108
      Purmorphamine Activator 99.89%
      Purmorphamine是一种平滑受体激动剂,EC50为1 μM。
    • HY-16582A
      Erismodegib Antagonist 99.68%
      Erismodegib (LDE225) 是有效,选择性的 Smo 拮抗剂, 抑制鼠和人Smo的 IC50 分别为 1.3 nM 和 2.5 nM。
    • HY-16391
      Glasdegib Inhibitor 99.31%
      Glasdegib (PF-04449913) 是一种口服有效的 smoothened 抑制剂。Glasdegib (PF-04449913) 结合到人 SMO (181-787氨基酸位点),IC50 为 4 nM。
    • HY-16582
      Erismodegib diphosphate Antagonist 99.83%
      Erismodegib diphosphate (LDE225 diphosphate) 是一种有效,选择性的 Smo 拮抗剂,抑制鼠和人Smo的IC50 分别为 1.3 nM 和 2.5 nM。
    • HY-12848B
      SAG hydrochloride Agonist 99.98%
      SAG (hydrochloride) 是一种有效的 Smo 受体激动剂,能够活化 Hedgehog 信号通路,Kd 值为 59 nM。
    • HY-16587
      Saridegib Inhibitor >99.0%
      Saridegib 是 Smo 的特异性有效抑制剂,这是 Hedgehog 通路中关键的跨膜信号蛋白。
    • HY-18287
      MRT-83 Antagonist >98.0%
      MRT-83 是有效的 Smo 拮抗剂,其 IC50 值在纳摩尔级别。
    • HY-N0836
      Jervine Inhibitor 99.03%
      Jervine(11-Ketocyclopamine)是甾体类生物碱,能阻断sonic hedgehog(Shh)信号通路,抑制Smo。
    • HY-13242
      Taladegib Inhibitor 99.76%
      Taladegib (LY2940680) 是一种 smoothened 受体拮抗剂。
    • HY-18636
      LEQ506 Inhibitor 98.27%
      LEQ506 是第二代 smoothened (smo) 抑制剂,在人类和小鼠中的 IC50 值分别为 2 和 4 nM。
    • HY-13809
      BMS-833923 Inhibitor
      BMS-833923 (XL-139)是口服生物相容性的Smoothened抑制剂,有抗肿瘤活性,能剂量依赖性抑制BODIPY cyclopamine与SMO的结合,IC50为21 nM。
    • HY-B0877
      Halcinonide Agonist 99.08%
      Halcinonide (SQ-18566) 是一糖皮质激素,用于治疗局部皮肤感染。
    • HY-100036
      MK-4101 Inhibitor 98.13%
    • HY-13459
      PF-5274857 Antagonist 98.12%
      PF-5274857是Smo拮抗剂,能抑制Hedgehog信号转导,IC50和Ki分别为5.8 nM和4.6 nM,能渗透入血脑屏障。
    • HY-100224
      SANT-1 Antagonist
      SANT-1 是一种有效的 Smo 拮抗剂,能够抑制 Hedgehog 通路,在 Shh-LIGHT2 和 SmoA1-LIGHT2 实验中,IC50 值分别为 20 nM 和 30 nM。
    Isoform Specific Products

    Your Search Returned No Results.

    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.