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    1. Stem Cell/Wnt
      TGF-beta/Smad
    2. TGF-beta/Smad

    TGF-beta/Smad

    Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

    TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

    TGF-beta/Smad 相关产品 (12):

    Cat. No. Product Name Effect Purity
    • HY-13013
      SIS3 Inhibitor >98.0%
      SIS3是可渗透细胞,选择性的 Smad3 抑制剂。 它抑制Smad3磷酸化的IC50 为3 μM。
    • HY-B0673
      Pirfenidone Inhibitor 99.98%
      Pirfenidone是一种用于治疗特发性肺纤维化的药物。 它抑制FGFREGFRPDGFRTGF-β,从而减缓肿瘤细胞增殖。
    • HY-100347A
      SRI-011381 hydrochloride Agonist 99.66%
      SRI-011381 hydrochloride是TGF-beta信号通路的激活剂。
    • HY-16268
      Kartogenin Activator 98.34%
      Kartogenin是人类间充质干细胞分化成软骨细胞的诱导剂。
    • HY-P0118
      Disitertide Inhibitor 98.12%
      Disitertide 是 TGF-β1 的一个抑制剂。
    • HY-101275
      EMT inhibitor-1 Inhibitor 98.71%
      EMT inhibitor-1 是 HippoTGF-βWnt 信号通路的抑制剂,并拥有抗肿瘤活性。
    • HY-N1584A
      Halofuginone hydrobromide Inhibitor 99.94%
      Halofuginone hydrobromide (RU-19110 hydrobromide) 是 Febrifugine 的一种低毒性衍生物,可从 Dichroa febrifuga 中分离出来。Halofuginone 是一种 ATP 竞争性的脯氨酰-tRNA 合成酶 (prolyl-tRNA synthetase) 抑制剂,Ki 为 18.3 nM。Halofuginone 通过抑制 TGF-β 活性可减轻骨关节炎。
    • HY-N1584
      Halofuginone Inhibitor 98.32%
      Halofuginone (RU-19110) 是 Febrifugine 的一种低毒性衍生物,可从 Dichroa febrifuga 中分离出来。Halofuginone 是一种 ATP 竞争性的脯氨酰-tRNA 合成酶 (prolyl-tRNA synthetase) 抑制剂,Ki 为 18.3 nM。Halofuginone 通过抑制 TGF-β 活性可减轻骨关节炎。
    • HY-N0158
      Oxymatrine Inhibitor >98.0%
      Oxymatrine是来自槐属物种根部的生物碱,具有抗炎,抗纤维化和抗肿瘤的作用。能抑制iNOS表达和TGF-β/Smad通路。
    • HY-N0439
      Asiaticoside Modulator 98.46%
      Asiaticoside 是从积雪草中分到的三萜皂苷化合物,在瘢痕疙瘩成纤维细胞中,通过活化 Smad7,抑制 TGF-βRI 和 TGF-βRII,抑制 TGF-β/Smad 信号通路;Asiaticoside 具有抗氧化、抗炎、抗溃疡等功效。
    • HY-B0252
      Hydrochlorothiazide Inhibitor 99.20%
      Hydrochlorothiazide是噻嗪类利尿化合物。
    • HY-N2033
      Chebulinic acid Inhibitor
      Chebulinic acid 是一个天然的M. tuberculosis DNA gyrase抑制剂,也能抑制SMAD-3 phosphorylation和H+ K+-ATPase的活性。
    Isoform Specific Products

    Your Search Returned No Results.

    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.

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