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    1. Others
    2. Thyroid Hormone Receptor

    Thyroid Hormone Receptor

    The thyroid hormone receptor (THR) is a type of nuclear receptor which belongs to a superfamily of eukaryotic transcription factors. It regulates gene expression in response to binding small, hydrophobic ligands. The receptors exhibits a modular structure, with functionally separable domains. The most highly conserved domains are the DNA-binding domain (DBD) and the ligand-binding domain (LBD). The DBD recognizes the specific DNA responses element for the receptor. The LBD participates in several activities, including hormone binding, homo- and/or heterodimerization, formation of heat-shock-protein complex, and transcriptional activation and repression. Unliganded thyroid hormone receptors are bound to DNA thyroid hormone response elements predominantly as homodimers, or as heterodimers with retinoid X-receptors, and are associated with a complex of proteins containing corepressor proteins. Ligand binding promotes corepressor dissociation and binding of a coactivator. Hormone binding induces changes in receptor conformation that control these properties and influence gene expression.

    Thyroid Hormone Receptor 相关产品 (14):

    Cat. No. Product Name Effect Purity
    • HY-A0070A
      3,3',5-Triiodo-L-thyronine Activator 98.75%
      3,3',5-Triiodo-L-thyronine是有效的甲状腺激素受体 TRαTRβ 的激动剂,Ki 值为2.3 nM。
    • HY-12216
      Resmetirom Agonist 99.43%
      Resmetirom (MGL-3196) 是高度选择性的THR-β激动剂,EC50值为0.21 μM。
    • HY-A0070
      3,3',5-Triiodo-L-thyronine sodium Activator 98.16%
      3,3',5-Triiodo-L-thyronine sodium 是一种有效的甲状腺激素 (thyroid hormone),可以结合并激活 β1甲状腺激素受体 (TRβ1)。
    • HY-14823
      Sobetirome Agonist >98.0%
      Sobetirome 是一种甲状腺激素受体 β (TRβ) 激动剂,Sobetirome可选择性结合到TRβ-1EC50 为 0.16 μM。
    • HY-18341
      L-Thyroxine >98.0%
      L-Thyroxine (Levothyroxine; T4) 是一种合成的甲状腺激素,用于治疗甲状腺功能减退症。DIO 酶将 L-Thyroxine (T4) 转化成具有生物活性的三碘甲状腺氨酸 (T3)。
    • HY-101406
      Thyroxine sulfate >98.0%
      Thyroxine sulfate是甲状腺激素代谢物。
    • HY-B1201
      Tiratricol 98.97%
      Tiratricol是甲状腺激素类似物, 已被用来抑制垂体促甲状腺激素分泌, 降低垂体外拟甲状腺素药效。
    • HY-10473
      Eprotirome Agonist >99.0%
      Eprotirome 是一个肝脏选择性甲状腺激素受体激动剂。
    • HY-18341A
      L-Thyroxine sodium salt pentahydrate 99.85%
      L-Thyroxine sodium salt pentahydrate (Levothyroxine; T4) 是一种合成的甲状腺激素,用于治疗甲状腺功能减退症。DIO 酶将 L-Thyroxine (T4) 转化成具有生物活性的三碘甲状腺氨酸 (T3)。
    • HY-P0002A
      Protirelin Acetate Activator 99.58%
      Protirelin Acetate 是一种高度保守的神经肽,发挥促甲状腺激素 (TSH) 水平的激素控制作用,及神经调节功能。
    • HY-111443
      TR antagonist 1 Antagonist 99.64%
      TR antagonist 1是高亲和力的甲状腺激素受体 (thyroid hormone receptor (TR)) 拮抗剂,对 TRα 和 TRβ 的IC50 值分别为 36 和 22 nM。
    • HY-P0002
      Protirelin Activator
      Protirelin 是一种高度保守的神经肽,发挥促甲状腺激素 (TSH) 水平的激素控制作用,及神经调节功能。
    • HY-100856
      PCO371 Agonist
      PCO371 是一种可口服的甲状旁腺激素受体 1 (PTHR1) 的完全抑制剂,对 PTHR2 无作用。
    • HY-U00220
      KAT681
      KAT681 是一种肝脏选择性的拟甲状腺素剂。
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