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    1. Apoptosis
    2. c-Myc

    c-Myc

    c-Myc is the master transcription factor for cell proliferation and is involved in numeroushematological and solidcancers.

    Proto-oncogene c-Myc, encoding one of the most important transcription factors, plays a pivotal role in tumor initiation and progression. c-Myc regulates hundreds of disparate target genes that participate numerous biological effects, such as cell proliferation, apoptosis, differentiation, and stem cell self-renewal. c-Myc is one of the four factors used in reprogramming somatic cells to induce pluripotent stem (iPS) cells and is implicated in maintaining cancer stem-like cells (CSCs).

    The transcription factor c-Myc is a key mediator of the Notch signaling–regulated T cell differentiation. In a well-established in vitro differentiation model of T lymphocytes from hematopoietic stem cells, Notch1 and 4 directly promotes c-Myc expression; dominant-negative (DN) c-Myc inhibits early T cell differentiation. Moreover, the c-Myc expression activated by Notch signaling increases the expression of survivin, an inhibitor of apoptosis (IAP) protein.

    c-Myc gene, as a transcription factor of hTERT, is over expressed in a variety of tumors.c-Myc and hTERT expression in local recurrent gastric cancer tissues is much higher than in primary gastric cancer tissues at the protein and mRNA levels.

    c-Myc 相关产品 (7):

    Cat. No. Product Name Effect Purity
    • HY-12702
      10058-F4 Inhibitor 99.92%
      10058-F4是 c-Myc 抑制剂,其阻止c-Myc-Max二聚化和c-Myc靶基因表达的反式激活。
    • HY-19735
      KJ Pyr 9 Inhibitor 99.25%
      KJ Pyr 9 是 MYC 的抑制剂。体外实验中, KJ Pyr 9 抑制 MYC 的 Kd 值为 6.5±1.0 nM。
    • HY-103038
      ML327 Inhibitor 98.04%
      ML327 是 MYC 的阻断剂,也可以去阻遏 E-钙粘蛋白转录和逆转上皮-间质转化 (EMT)。
    • HY-100996
      10074-G5 Inhibitor
      10074-G5是c-Myc-Max二聚化抑制剂,IC50值为146 μM。
    • HY-100669
      Mycro 3 Inhibitor 98.63%
      Mycro 3 是一种有效的选择性 c-Myc 抑制剂。
    • HY-111411
      IZCZ-3 Inhibitor
      IZCZ-3是有效的c-MYC 转录抑制剂,具有抗肿瘤活性。
    • HY-12703
      KSI-3716 Inhibitor
      KSI-3716是 c-Myc 的抑制剂。
    Isoform Specific Products

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    Sorry. There is currently no product that acts on isoform together.

    Please try each isoform separately.

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