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    1. GPCR/G Protein
      Neuronal Signaling
    2. mAChR


    mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

    mAChR 相关产品 (108):

    Cat. No. Product Name Effect Purity
    • HY-B0726
      Pilocarpine Hydrochloride Agonist 99.92%
      Pilocarpine Hydrochloride 是一种选择性的 M3 型毒蕈碱乙酰胆碱受体 (M3 muscarinic receptor) 激动剂。
    • HY-N0296A
      Scopolamine hydrobromide Antagonist >98.0%
      Scopolamine hydrobromide 是高亲和力的 (nM 级别) 毒蕈碱 (muscarinic) 拮抗剂。Scopolamine 可逆抑制 5-HT3 受体反应,IC50 为 2.09 μM。
    • HY-B1208
      Carbamoylcholine chloride Agonist >98.0%
      Carbamoylcholine氯化物用来研究nAChR和mAchR的介导的反应, 包括平滑肌收缩, 肠运动, 与神经信号。Carbamoylcholine是乙酰胆碱类似物, 激活乙酰胆碱受体 (AChR), Carbamoylcholine是nAChR和mAchR受体激动剂, 针对不同的受体, Ki值为10到10,000 nM。
    • HY-B0394
      Atropine sulfate monohydrate Antagonist 99.62%
    • HY-B0106
      Levetiracetam Inhibitor
      Levetiracetam (UCB L059) 是一种选择性 M2 毒蕈碱乙酰胆碱受体 (mAChR) 抑制剂。抗癫痫。
    • HY-12157
      VU 0238429 Modulator 99.96%
      VU 0238429 是 mAChR M5 的正变构调节剂,其 EC50 值为 1.16 μM。
    • HY-120081A
      Metixene hydrochloride hydrate Inhibitor 99.83%
      Metixene hydrochloride hydrate 是一种抗胆碱能、抗帕金森剂,能够有效抑制二苯羟乙酸奎宁酯与毒蕈碱受体 (muscarinic receptor) 结合,IC50Kd 值分别为 55 nM 和 15 nM。
    • HY-122190
      TAK-071 Modulator
      TAK-071是一种新型, 高效,选择性的毒蕈碱乙酰胆碱受体1 (M1R)正变构调节剂。 TAK-071激活M1R的EC50为520nM。
    • HY-A0012
      Darifenacin hydrobromide Antagonist
      Darifenacin HBr(UK88525)是选择性M3蕈毒碱受体拮抗剂,pKi为8.9。
    • HY-B0489
      Arecoline hydrobromide Agonist >99.0%
    • HY-B1205
      Atropine Antagonist 99.55%
    • HY-17037
      Pirenzepine dihydrochloride 99.86%
      Pirenzepine dihydrochloride (LS519) 是一种选择性 M1 型毒蕈碱受体拮抗剂。
    • HY-A0083
      Methacholine chloride Agonist >98.0%
      Methacholine chloride是选择性毒蕈碱受体mAChR激动剂。
    • HY-12100
      Umeclidinium bromide Antagonist 99.72%
      Umeclidinium bromide 是一种 mAChR 拮抗剂。Umeclidinium bromide 作用于克隆的人 M1-M5 mAChRs,Ki 为 0.05 到 0.16 nM。
    • HY-B0499A
      Otilonium bromide Inhibitor
    • HY-17465
      Glycopyrrolate Antagonist >98.0%
      Glycopyrrolate(Glycopyrronium Br)是竞争性毒蕈碱拮抗剂,可解痉挛。
    • HY-12980
      Batefenterol Antagonist 98.30%
      Batefenterol (GSK961081;TD-5959)是一种新的muscarinic受体拮抗剂和β2-肾上腺素受体激动剂; 对hM2,hM3和β2-肾上腺素受体有高亲和力,Ki值分别为1.4, 1.3和3.7nM。
    • HY-13204
      Biperiden Hydrochloride Inhibitor >98.0%
      Biperiden(KL 373)盐酸盐是M1胆碱受体阻断剂,可作用于帕金森症。
    • HY-76772
      Cevimeline hydrochloride hemihydrate Agonist >98.0%
    • HY-13410
      Xanomeline oxalate Agonist 98.63%
    Isoform Specific Products

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